Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 555)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0768111	0.1087655	0.4878200
Weighted median	23	0.0421721	0.0565553	0.4558621
Inverse variance weighted	23	0.0388690	0.0416762	0.3510051
Simple mode	23	0.0521930	0.0951212	0.5887373
Weighted mode	23	0.0615743	0.0680171	0.3751268

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.93254	21	0.2500979
Inverse variance weighted	25.10307	22	0.2921713

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.00233	0.0061479	0.7084986

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007907	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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