Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 554)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1083521	0.1014340	0.2975547
Weighted median	23	0.0928253	0.0568955	0.1027842
Inverse variance weighted	23	0.0225345	0.0395062	0.5684027
Simple mode	23	0.1113219	0.0936374	0.2471689
Weighted mode	23	0.1168413	0.0795826	0.1562094

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.68447	21	0.4178836
Inverse variance weighted	22.55687	22	0.4271012

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0052701	0.0057335	0.3684485

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006936	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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