Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 553)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0305686	0.1083263	0.7805602
Weighted median	23	0.0036933	0.0539702	0.9454412
Inverse variance weighted	23	0.0160035	0.0415810	0.7003297
Simple mode	23	-0.0141844	0.0777926	0.8569889
Weighted mode	23	-0.0325372	0.0599263	0.5926211

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.73128	21	0.2589899
Inverse variance weighted	24.98821	22	0.2976389

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.00286	0.0061231	0.6452528

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007623	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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