Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 552)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1923202	0.1189037	0.1207057
Weighted median	23	0.0442450	0.0604109	0.4639233
Inverse variance weighted	23	0.0183515	0.0480602	0.7025765
Simple mode	23	0.0882084	0.1118862	0.4388898
Weighted mode	23	0.0803433	0.1025573	0.4417454

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.79856	21	0.0961113
Inverse variance weighted	33.38387	22	0.0566744

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0106835	0.0067211	0.1268782

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010183	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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