Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 551)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0303938	0.0998207	0.7637561
Weighted median	23	-0.0170915	0.0551077	0.7564487
Inverse variance weighted	23	-0.0103104	0.0390159	0.7915788
Simple mode	23	0.0049601	0.0790204	0.9505163
Weighted mode	23	-0.0105032	0.0573887	0.8564589

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.64261	21	0.7325299
Inverse variance weighted	16.83887	22	0.7721912

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0024996	0.0056423	0.662285

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005124	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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