Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 550)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0851754	0.1061771	0.4314216
Weighted median	23	0.0651077	0.0607896	0.2841541
Inverse variance weighted	23	-0.0045687	0.0413525	0.9120278
Simple mode	23	0.1320516	0.1241727	0.2991116
Weighted mode	23	0.1232339	0.0820722	0.1474363

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.76081	21	0.3047918
Inverse variance weighted	24.71491	22	0.3109017

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0055112	0.0060017	0.3688997

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007493	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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