Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 55)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0556248	0.1043743	0.5996727
Weighted median	23	0.0151254	0.0560872	0.7874088
Inverse variance weighted	23	0.0246866	0.0405151	0.5423144
Simple mode	23	0.0024776	0.0961812	0.9796813
Weighted mode	23	-0.0009364	0.0691548	0.9893190

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.95965	21	0.3461337
Inverse variance weighted	23.72368	22	0.3618786

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0049319	0.0058997	0.4125916

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000731	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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