Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 549)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0800553	0.1145152	0.4921727
Weighted median	23	-0.0095249	0.0577549	0.8690077
Inverse variance weighted	23	-0.0361188	0.0449771	0.4219463
Simple mode	23	-0.0951038	0.0985923	0.3452214
Weighted mode	23	0.0084971	0.0656005	0.8981170

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.63818	21	0.1507145
Inverse variance weighted	29.23693	22	0.1382199

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0071342	0.0064729	0.282863

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009119	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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