Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 548)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0096335	0.0998206	0.9240325
Weighted median	23	-0.0048172	0.0518219	0.9259374
Inverse variance weighted	23	-0.0270756	0.0390156	0.4877026
Simple mode	23	-0.0660504	0.0941526	0.4903307
Weighted mode	23	0.0078961	0.0630977	0.9015491

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.57709	21	0.6755874
Inverse variance weighted	17.73671	22	0.7214795

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0022543	0.0056423	0.6935354

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005521	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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