Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 547)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1538796	0.0998201	0.1381132
Weighted median	23	0.0968891	0.0528676	0.0668511
Inverse variance weighted	23	0.0818797	0.0390155	0.0358483
Simple mode	23	0.1025710	0.0867214	0.2495278
Weighted mode	23	0.1113541	0.0633218	0.0925596

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.44214	21	0.7443172
Inverse variance weighted	17.05622	22	0.7602511

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0044215	0.0056423	0.4420042

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006503	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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