Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 546)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1017164	0.1052543	0.3448488
Weighted median	23	-0.0728653	0.0619359	0.2394099
Inverse variance weighted	23	-0.0175784	0.0409092	0.6674190
Simple mode	23	0.1444065	0.1335136	0.2911499
Weighted mode	23	-0.1267445	0.1050325	0.2403569

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.34952	21	0.3256295
Inverse variance weighted	24.18814	22	0.3374454

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.005167	0.0059495	0.3949571

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007391	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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