Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 545)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0497906	0.1111141	0.6586673
Weighted median	23	-0.0272706	0.0581369	0.6390149
Inverse variance weighted	23	0.0085057	0.0425957	0.8417264
Simple mode	23	-0.0975164	0.1078175	0.3755513
Weighted mode	23	-0.0302210	0.0695173	0.6679957

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.02083	21	0.2056561
Inverse variance weighted	26.22273	22	0.2422421

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0025353	0.0062807	0.6905399

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007961	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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