Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 544)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0403499	0.1062377	0.7079020
Weighted median	23	-0.0097688	0.0587431	0.8679228
Inverse variance weighted	23	-0.0167261	0.0408973	0.6825564
Simple mode	23	-0.0005853	0.0934939	0.9950614
Weighted mode	23	0.0208783	0.0681640	0.7622601

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.78724	21	0.3034814
Inverse variance weighted	24.17314	22	0.3382198

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.003505	0.0060051	0.5656528

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000738	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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