Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 543)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0561293	0.1220304	0.6502702
Weighted median	23	0.0487691	0.0625779	0.4357832
Inverse variance weighted	23	0.0333346	0.0472983	0.4809511
Simple mode	23	-0.0207293	0.1092050	0.8511906
Weighted mode	23	0.0322789	0.0711785	0.6546359

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.38487	21	0.0674870
Inverse variance weighted	32.33298	22	0.0718936

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0054939	0.0068977	0.4346612

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010018	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8