Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 542)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0567040	0.1070658	0.6019313
Weighted median	23	0.0446886	0.0571732	0.4344287
Inverse variance weighted	23	-0.0232679	0.0415213	0.5752166
Simple mode	23	0.0141084	0.1053722	0.8947059
Weighted mode	23	0.0353083	0.0753933	0.6441616

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.15907	21	0.2854150
Inverse variance weighted	24.91666	22	0.3010768

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0049111	0.0060519	0.4261842

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007658	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8