Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 541)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0561772	0.1138511	0.6268316
Weighted median	23	0.1071983	0.0573761	0.0617139
Inverse variance weighted	23	0.0692361	0.0449346	0.1233604
Simple mode	23	0.1434584	0.1102401	0.2066105
Weighted mode	23	0.1024836	0.0654280	0.1315371

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.31894	21	0.1605439
Inverse variance weighted	29.18213	22	0.1397340

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0077016	0.0064354	0.244738

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009797	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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