Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 540)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0291445	0.1054211	0.7848991
Weighted median	23	-0.0072511	0.0563095	0.8975385
Inverse variance weighted	23	-0.0157348	0.0404618	0.6973641
Simple mode	23	0.1322737	0.0941132	0.1738457
Weighted mode	23	-0.0071932	0.0621010	0.9088369

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.42262	21	0.3218657
Inverse variance weighted	23.66121	22	0.3652354

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.002756	0.0059589	0.6484743

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007219	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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