Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 54)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1211883	0.1178826	0.3156264
Weighted median	23	-0.0049567	0.0598601	0.9340074
Inverse variance weighted	23	-0.0261862	0.0458308	0.5677518
Simple mode	23	-0.0059002	0.1069605	0.9565070
Weighted mode	23	-0.0169098	0.0808802	0.8363156

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.28839	21	0.1072481
Inverse variance weighted	30.35755	22	0.1100298

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0058341	0.0066634	0.3911765

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009335	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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