Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 539)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0401235	0.1091033	0.7167354
Weighted median	23	-0.0170089	0.0650062	0.7935913
Inverse variance weighted	23	0.0185822	0.0420012	0.6581855
Simple mode	23	0.1736271	0.1340757	0.2087487
Weighted mode	23	-0.1048099	0.0952869	0.2832489

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.08836	21	0.2433576
Inverse variance weighted	25.49661	22	0.2739207

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0036051	0.0061671	0.565061

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007795	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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