Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 538)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1698960	0.1171014	0.1615975
Weighted median	23	0.0579493	0.0580052	0.3177769
Inverse variance weighted	23	0.0552984	0.0459059	0.2283564
Simple mode	23	0.0373017	0.0914852	0.6874087
Weighted mode	23	0.0551363	0.0638292	0.3970127

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.90137	21	0.1163897
Inverse variance weighted	30.45707	22	0.1077719

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0070375	0.0066192	0.2997668

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009837	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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