Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 537)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0954293	0.0998203	0.3499435
Weighted median	23	0.0195002	0.0534782	0.7153810
Inverse variance weighted	23	0.0152986	0.0390156	0.6949727
Simple mode	23	-0.0444452	0.0957184	0.6469714
Weighted mode	23	0.0333858	0.0645781	0.6103270

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.58438	21	0.6117822
Inverse variance weighted	19.34499	22	0.6239396

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0049208	0.0056423	0.3930019

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005909	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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