Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 536)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1667644	0.1118959	0.1509992
Weighted median	23	-0.0298549	0.0649678	0.6458507
Inverse variance weighted	23	0.0096853	0.0450347	0.8297174
Simple mode	23	-0.0786207	0.1319187	0.5572723
Weighted mode	23	-0.0722886	0.0989915	0.4729419

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.38954	21	0.1919835
Inverse variance weighted	29.31250	22	0.1361533

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0096463	0.006325	0.1421488

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008901	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8