Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 535)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0038812	0.1150789	0.9734135
Weighted median	23	-0.0036734	0.0570066	0.9486215
Inverse variance weighted	23	0.0512311	0.0442276	0.2467208
Simple mode	23	-0.0121980	0.1101173	0.9128010
Weighted mode	23	-0.0021500	0.0673522	0.9748224

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.91089	21	0.1426967
Inverse variance weighted	28.27069	22	0.1668829

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0033844	0.0065048	0.6082983

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009089	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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