Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 534)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0299717	0.0998204	0.7669340
Weighted median	23	-0.0919314	0.0535677	0.0861307
Inverse variance weighted	23	-0.0590473	0.0390156	0.1301709
Simple mode	23	-0.0870664	0.0792500	0.2838080
Weighted mode	23	-0.0778104	0.0623913	0.2254617

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.19739	21	0.6990735
Inverse variance weighted	18.13608	22	0.6978901

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0054666	0.0056423	0.3436406

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000619	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8