Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 533)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1231159	0.1292895	0.3518029
Weighted median	23	-0.0865439	0.0602314	0.1507586
Inverse variance weighted	23	-0.0587702	0.0497144	0.2371437
Simple mode	23	-0.1600664	0.1202030	0.1966141
Weighted mode	23	-0.1218778	0.0801948	0.1428108

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.23111	21	0.0266292
Inverse variance weighted	35.72159	22	0.0325179

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0039515	0.0073082	0.5944043

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011511	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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