Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 532)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1479599	0.0998189	0.1531169
Weighted median	23	-0.0274834	0.0616834	0.6559182
Inverse variance weighted	23	0.0070689	0.0401720	0.8603203
Simple mode	23	-0.0144413	0.1325133	0.9142063
Weighted mode	23	-0.1045536	0.0883500	0.2492804

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.47706	21	0.4912496
Inverse variance weighted	23.32413	22	0.3836250

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0095204	0.0056423	0.1063398

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007078	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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