Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 531)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0188848	0.0998207	0.8517627
Weighted median	23	0.0103087	0.0532913	0.8466133
Inverse variance weighted	23	-0.0101275	0.0390158	0.7951915
Simple mode	23	0.0062556	0.0961843	0.9487310
Weighted mode	23	0.0313747	0.0625585	0.6209831

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.76834	21	0.9165212
Inverse variance weighted	12.77742	22	0.9391833

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0005378	0.0056424	0.9249707

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003892	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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