Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 530)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0917512	0.1144660	0.4317852
Weighted median	23	0.0571534	0.0557404	0.3051980
Inverse variance weighted	23	0.0439636	0.0439245	0.3168793
Simple mode	23	0.0056475	0.0926758	0.9519583
Weighted mode	23	0.0407648	0.0658498	0.5422369

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.61404	21	0.1514407
Inverse variance weighted	27.88456	22	0.1795388

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0029346	0.0064702	0.654796

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008834	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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