Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 53)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0417660	0.0998206	0.6798947
Weighted median	23	-0.0147989	0.0579882	0.7985644
Inverse variance weighted	23	0.0304128	0.0390156	0.4356839
Simple mode	23	-0.0561381	0.0913416	0.5451263
Weighted mode	23	-0.0167915	0.0678270	0.8067680

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.60900	21	0.7912019
Inverse variance weighted	15.62427	22	0.8340858

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0006972	0.0056424	0.9028338

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004919	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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