Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 529)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1241831	0.0998200	0.2271817
Weighted median	23	-0.0098218	0.0562065	0.8612802
Inverse variance weighted	23	-0.0172228	0.0390155	0.6588974
Simple mode	23	0.0415537	0.0922042	0.6566372
Weighted mode	23	-0.0304755	0.0679940	0.6583859

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.25270	21	0.5053093
Inverse variance weighted	21.60791	22	0.4834890

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0065684	0.0056423	0.2574244

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006607	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8