Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 528)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0490638	0.1050077	0.6451399
Weighted median	23	0.0621016	0.0556028	0.2640463
Inverse variance weighted	23	0.0109088	0.0402478	0.7863585
Simple mode	23	0.0594955	0.1052251	0.5775153
Weighted mode	23	0.0532810	0.0762178	0.4918382

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.23936	21	0.3313503
Inverse variance weighted	23.41181	22	0.3787974

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0023431	0.0059355	0.6970036

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007118	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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