Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 527)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1344121	0.0998202	0.1924823
Weighted median	23	-0.0363863	0.0552315	0.5100270
Inverse variance weighted	23	-0.0053777	0.0390158	0.8903710
Simple mode	23	-0.0588548	0.0983013	0.5554760
Weighted mode	23	-0.0588548	0.0598224	0.3358981

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.20054	21	0.8608322
Inverse variance weighted	16.17284	22	0.8072160

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.007924	0.0056423	0.1748217

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004907	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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