Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 526)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0666732	0.1068340	0.5392946
Weighted median	23	-0.0623218	0.0604434	0.3025041
Inverse variance weighted	23	-0.0244377	0.0416222	0.5571156
Simple mode	23	-0.0839269	0.1035364	0.4262761
Weighted mode	23	-0.0671010	0.0722890	0.3633598

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.05461	21	0.2904198
Inverse variance weighted	25.03794	22	0.2952636

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0055951	0.0060388	0.3646966

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007706	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8