Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 525)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0672917	0.1136822	0.5602179
Weighted median	23	-0.0606687	0.0626920	0.3331813
Inverse variance weighted	23	-0.0437379	0.0434646	0.3142773
Simple mode	23	-0.0910658	0.1301680	0.4915077
Weighted mode	23	-0.1267598	0.1120652	0.2701826

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.23914	21	0.1630773
Inverse variance weighted	27.30486	22	0.1998757

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0014465	0.006426	0.8240804

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008655	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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