Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 524)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0776057	0.1403451	0.5861277
Weighted median	23	-0.0345444	0.0657011	0.5990397
Inverse variance weighted	23	0.0222391	0.0538276	0.6794935
Simple mode	23	-0.0436543	0.1372367	0.7534126
Weighted mode	23	-0.0954927	0.0923687	0.3124512

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	41.51395	21	0.0048407
Inverse variance weighted	41.87709	22	0.0064686

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0034001	0.007933	0.6725807

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012787	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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