Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 523)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0332983	0.0998201	0.7420018
Weighted median	23	-0.0590101	0.0556644	0.2890971
Inverse variance weighted	23	-0.0343276	0.0390156	0.3789451
Simple mode	23	0.0706280	0.0964407	0.4716878
Weighted mode	23	-0.0531995	0.0707249	0.4599019

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.29323	21	0.7529557
Inverse variance weighted	16.83497	22	0.7724032

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0041529	0.0056423	0.4698555

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005336	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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