Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 522)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0838959	0.0998203	0.4101132
Weighted median	23	-0.0845216	0.0550536	0.1247200
Inverse variance weighted	23	-0.0393362	0.0390156	0.3133496
Simple mode	23	-0.0981098	0.0907604	0.2914153
Weighted mode	23	-0.0874913	0.0667216	0.2032815

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.48497	21	0.8906900
Inverse variance weighted	13.72018	22	0.9111124

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0027364	0.0056423	0.6327124

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004466	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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