Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 521)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0114844	0.1098489	0.9177271
Weighted median	23	0.0253266	0.0579547	0.6621066
Inverse variance weighted	23	0.0278533	0.0420993	0.5082204
Simple mode	23	0.0751356	0.0963549	0.4438292
Weighted mode	23	0.0675725	0.0778663	0.3948703

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.43199	21	0.2289392
Inverse variance weighted	25.61530	22	0.2685648

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0024157	0.0062092	0.7011509

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007916	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8