Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 520)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2241997	0.1054521	0.0455216
Weighted median	23	-0.1264952	0.0571737	0.0269342
Inverse variance weighted	23	-0.0526956	0.0431590	0.2220996
Simple mode	23	0.1490284	0.1301411	0.2644608
Weighted mode	23	-0.1688228	0.0623645	0.0128737

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.43748	21	0.3211036
Inverse variance weighted	26.92189	22	0.2142083

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0105322	0.0059607	0.0917723

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008711	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8