Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 52)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1171046	0.1126092	0.3102025
Weighted median	23	-0.0018397	0.0570278	0.9742653
Inverse variance weighted	23	-0.0466445	0.0454864	0.3051457
Simple mode	23	-0.0121160	0.0924037	0.8968720
Weighted mode	23	-0.0121160	0.0605965	0.8433601

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.72613	21	0.1801032
Inverse variance weighted	29.90247	22	0.1208541

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0100557	0.0063651	0.1290954

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009494	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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