Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 519)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0530999	0.0998205	0.6003411
Weighted median	23	-0.0863402	0.0547822	0.1150111
Inverse variance weighted	23	-0.0626697	0.0390158	0.1082159
Simple mode	23	-0.0778047	0.0860326	0.3755999
Weighted mode	23	-0.0941087	0.0679081	0.1796894

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.71282	21	0.9183492
Inverse variance weighted	12.72367	22	0.9405824

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0005877	0.0056424	0.9180344

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004637	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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