Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 518)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1092001	0.0998209	0.2863623
Weighted median	23	-0.0087792	0.0541126	0.8711178
Inverse variance weighted	23	-0.0205957	0.0390157	0.5975810
Simple mode	23	0.0139364	0.0875755	0.8750134
Weighted mode	23	-0.0065033	0.0625076	0.9180805

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.87807	21	0.5929619
Inverse variance weighted	19.80803	22	0.5950466

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0054412	0.0056423	0.3458468

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006087	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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