Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 517)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1038237	0.1213996	0.4020804
Weighted median	23	-0.0061859	0.0555985	0.9114102
Inverse variance weighted	23	-0.0118738	0.0475275	0.8027193
Simple mode	23	-0.0331936	0.0851180	0.7003075
Weighted mode	23	-0.0079374	0.0608854	0.8974618

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.06080	21	0.0726520
Inverse variance weighted	32.64644	22	0.0670235

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0071049	0.0068621	0.3122619

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000992	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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