Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 516)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1570667	0.0998198	0.1305484
Weighted median	23	-0.0461346	0.0555249	0.4060403
Inverse variance weighted	23	-0.0099064	0.0390154	0.7995659
Simple mode	23	0.0450267	0.1027618	0.6655386
Weighted mode	23	-0.0976408	0.0623430	0.1315766

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.05792	21	0.7075890
Inverse variance weighted	19.62328	22	0.6065915

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0090371	0.0056423	0.1241646

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005966	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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