Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 515)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0501352	0.1208169	0.6823737
Weighted median	23	0.0478682	0.0578151	0.4076973
Inverse variance weighted	23	0.0869905	0.0462575	0.0600303
Simple mode	23	0.0460477	0.0935401	0.6273999
Weighted mode	23	0.0391465	0.0745443	0.6047359

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.76491	21	0.0776605
Inverse variance weighted	30.92581	22	0.0976436

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0022633	0.0068291	0.7436157

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010876	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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