Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 514)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2193957	0.1025081	0.0442273
Weighted median	23	0.0482045	0.0597821	0.4200492
Inverse variance weighted	23	0.0042586	0.0437237	0.9224110
Simple mode	23	0.0376777	0.1111682	0.7378798
Weighted mode	23	0.0599682	0.0826193	0.4755896

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.14798	21	0.3910259
Inverse variance weighted	27.63114	22	0.1882297

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0132118	0.0057943	0.0331518

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008376	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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