Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 512)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0133484	0.1093243	0.9039815
Weighted median	23	-0.0702468	0.0561156	0.2106349
Inverse variance weighted	23	-0.0494023	0.0418752	0.2381000
Simple mode	23	-0.0955305	0.0893156	0.2964019
Weighted mode	23	-0.0677533	0.0651303	0.3095114

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.18945	21	0.2390521
Inverse variance weighted	25.34343	22	0.2809350

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0022141	0.0061795	0.7237028

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008165	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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