Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 511)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0086761	0.0998199	0.9315608
Weighted median	23	-0.0279601	0.0565688	0.6211178
Inverse variance weighted	23	-0.0114665	0.0390156	0.7688377
Simple mode	23	0.0426644	0.0934904	0.6526116
Weighted mode	23	-0.0593503	0.0761859	0.4442676

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.55685	21	0.6768492
Inverse variance weighted	17.55777	22	0.7318623

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0001714	0.0056423	0.9760581

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005347	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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