Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 510)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0869288	0.0998208	0.3936836
Weighted median	23	0.0382616	0.0540911	0.4793463
Inverse variance weighted	23	-0.0054249	0.0390156	0.8894160
Simple mode	23	0.0295717	0.0945751	0.7574685
Weighted mode	23	0.0503071	0.0549303	0.3696834

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.75955	21	0.4737101
Inverse variance weighted	21.76988	22	0.4736937

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0056714	0.0056423	0.3262656

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006602	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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