Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 51)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1705325	0.1022800	0.1102983
Weighted median	23	-0.0413212	0.0548951	0.4516122
Inverse variance weighted	23	-0.0039492	0.0418685	0.9248518
Simple mode	23	-0.0294778	0.0892436	0.7442930
Weighted mode	23	-0.0627309	0.0569323	0.2824360

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.04762	21	0.3967699
Inverse variance weighted	25.33480	22	0.2813338

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0102298	0.0057813	0.0913389

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000768	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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